Specificity and HLA-restriction of CD4 T Cells Associated with Neonatal Alloimmune Thrombocytopenia

T cell responses associated with neonatal alloimmune thrombocytopenia: Isolation of HPA-1a- specific, HLA-DRB3*0101-restricted CD4 T cells. Short title: HPA-1a-SPECIFIC T CELLS ASSOCIATED WITH NAIT Authors:

T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.

T-cell responses have been implicated in the development of HPA-1a-induced neonatal alloimmune thrombocytopenia (NAIT). However, HPA-1a-specific T cells have neither been isolated nor characterized. Here, we aimed to determine whether HPA-1a-specific T cells could be isolated from HPA-1a-immunized women. In the present study, peripheral blood mononuclear cells (PBMCs) from an HPA-1a-alloimmuniz...

Neonatal alloimmune thrombocytopenia due to HLA-A2 antibody.

A male, full-term baby with thrombocytopenia was born by a G3P2A1 mother who was not associated with autoimmune disease. Platelet antibody screening was positive by using lymphocytotoxicity test, platelet suspension immunofluorescence test and solid-phase red cell adherence test. The identified HLA antibody was of A2 specificity. It was confirmed by testing the mother's and the baby's sera agai...

Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update

This review focuses on reports on fetal/neonatal alloimmune thrombocytopenia (FNAITP) – presumably due to alloimmunization to HLA antigens – published during the last 6 years. Platelets express HLA class I antigens, and HLA antibodies are known to adversely affect the success of platelet transfusions. Likewise, it is conceivable that HLA antigens can serve as targets leading to HLA antibody-ind...

B-cell-directed therapy for chronic graft-versus-host disease.

fetal alloimmune thrombocytopenia-a less invasive option? J Obstet study of the antenatal management of feto-maternal alloimmune thrombocytopenia. Antenatal noninvasive treatment of patients at risk for alloimmune thrombocytopenia without a history of intracranial hemorrhage. Am Hung C, et al. Antepartum treatment without early cordocentesis for standard-risk alloimmune thrombocytopenia: a rand...